From Statistical to Biological Interactions via Omics Integration

From Statistical to Biological Interactions via Omics Integration

245 Pages · 2016 · 8.95 MB · English

presentation and teaching skills that I hope will be useful in my future life journey. My PhD already developed bioinformatics workflows such de novo genome assembly tools among others. learning and systems biology to develop omics-based genetic and epistatic statistical networks. The.

From Statistical to Biological Interactions via Omics Integration free download


From Statistical to Biological Interactions via Omics Integration Kyrylo Bessonov Promotor: Prof Dr Dr Kristel Van Steen Chair: Prof Dr Pierre Geurts Inte rnal Jury: Prof Dr Vi ncent Bours Prof Dr Patrick Meyer External Jury: Prof Dr Monika Stoll Prof Dr Benno Schwikowsk i Université de Liège Faculté des Sciences Appliquées Département d'Electricit é, Electronique et Informatique Thèse présentée en vue de l'obtention du Grade de Docteur en Sciences de l'Ingénieur Juin 2016 Summary The XXI century opened a new ‘Bi g Data’ era in which, thanks to rapid technological advancements and appearance of high throughput technologies , vast amounts of unstructured omics data (eg, transcriptomic, genomic, etc) are generated every day This thesis mainly focuses on solving the problems related diverse omics data integration and interaction identification tasks Particular attention is given to useful knowledge extraction in the context of complex diseases including pathological mechanisms with the development of software tool s and pipelines The diseases covered included glioblastoma multiforme, asthma, and ankylosing spondylitis Interactions detection in genomic data requires standardization of the protocols In Chapter 3, w e tested the impact of different settings in a gen ome wide association interaction study (GWAIS) Some of the settings includ ed marker selection strategy, the LD pruning, lower order effects adjustment , analytical tool We were able to show that even small changes in each setting can have drastic impacts requiring careful assessment of proper settings and results comparisons across several analysis protocols The greatest impact was attributed to the input dataset composition highlighting the importance of the marker selection strategy and use of prior kno wledge Expression of genes can be affected by nearby ( ‘cis ’) or distant ( ‘trans ’) genotypes Thus, we developed methodology to identify complex

------------- Read More -------------

Download from-statistical-to-biological-interactions-via-omics-integration.pdf

From Statistical to Biological Interactions via Omics Integration related documents

Simple Steps to Online Fundraising Success

1 Pages · 2010 · 32 KB · English

Simple Steps to Online Fundraising Success 1- Sign up your community event online link back to your fundraising page. Please read our tips on emailing for more

Binders for radioactive waste forms made from pretreated calcined sodium bearing waste

8 Pages · 2006 · 187 KB ·

Although calcination of the pretreated SBW produces a instance metakaolin mixed with NaOH proved to be a superior binder for solidification.

Disclosing to Better Shine

44 Pages · 2008 · 8.09 MB ·

Perini line, as well as to ensure the succession of the service staff in the conversion a first for France: wood gasification technology, the 30-million- .. The Premio Venezia competition jury, made up of various. Québec and Italian .. Patricia holds an advanced graduate diploma in public relatio

An integrated approach to product design and process selection

48 Pages · 2011 · 2.15 MB ·

Narayan Raman .. M? < Bs% .. a geometric series given by TEMP(y) = r * TEMP(

ENTERPRISE, ENBRIDGE AND ANADARKO TO JOINTLY

4 Pages · 2012 · 111 KB · English

ENTERPRISE, ANADARKO, AND DCP MIDSTREAM TO JOINTLY DEVELOP NEW NGL PIPELINE TO SERVE COLORADO'S DENVER-JULESBURG BASIN Houston and The Woodlands, Texas and Denver

How to Log in to your email account

7 Pages · 2004 · 820 KB · English

The following manual provides information on how to use your Grande Communications® email account. It will instruct you on how to send, receive, and

The Promotion of American Culture through Hollywood Movies to the World

8 Pages · 2012 · 644 KB · English

The Promotion of American. Culture through Hollywood. Movies to the World. Wanwarang Maisuwong. Thammasat University. Abstract. State and non-state actors pay more attention to the use of media, because media reach amount of audiences and the messages conveyed through media are obvious.

Mapping the Cybernetic Principles of Viable System Model to Enterprise Service Bus

11 Pages · 2014 · 642 KB · English

mapping of the cybernetic principles of the Viable System Model. (VSM) to an Enterprise .. complexity of management of distinct middleware infrastructures that drive the service-oriented integration. III. VIABLE ENTERPRISE SERVICE BUS MODEL .. organisation (e.g. ITIL, COBIT, customised, etc.) to.

UFFO/Lomonosov: The Payload for the Observation of Early Photons from Gamma Ray Bursts

21 Pages · 2017 · 5.99 MB · English

Leung Center for Cosmology and Particle Astrophysics, National Taiwan University, 1 Roosevelt. Road National Space Organization, 9 Prosperity 1st Road, Hsinchu Science Park, HsinChu, 30078,. Taiwan. 12 . the solid angle view of 70° × 70° at the speed of a second after receiving the trigger from

2846. ST 2847. Questions to Area Manager

6 Pages · 2011 · 264 KB · English

Swords Co. Dublin e) Proposed granting of 20 year lease of Youth Services Building, Darndale, Dublin 17 to City of Dublin Youth Services Board (CDVEC). 2852.