Capsules and It's Technology: An Overview

Capsules and It's Technology: An Overview

7 Pages · 2014 · 356 KB · English

The gelatin cap-sule shell may be soft or hard depending on their formulation. Capsules are over traditional dosage forms such as tablets, hard hermetically sealed, one-piece capsule with a liquid or. semisolid fill. The softgel consists of two major. components, the gelatin shell and the fill. I

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REVIEW ARTICLE ISSN: 23488948 Vol: 2; Issue: 9 CAPSULES AND IT’ S TECHNOLOGY: AN OVERVIEW BSrividya*, Dr C SowmyaCSurya Prakash Reddy Raghavendra Institute of Pharmaceutical Education a nd Research, Ananthapuramu, Andhra Pradesh, India – 515721 Date Received: 31Aug2014 Date of Accepted: 14Sep2014 Date Published: 17 Sep 2014 727 Abstract: The gelatin capsule shell may be soft or hard depe nding on their formulation Capsules are intended to be swallowed whole by the patient In instances where patients (especi ally children) are unable to swallow capsules, the contents of the capsule can be removed and added (eg, sprinkled) on soft food immediately before ingestion In the manufacture of pharmaceuticals, encapsulation refers to a range of techniques used to enclose medicines in a relatively stable shell known as a capsule, allowing them to, for example, be tak en orally or be used as suppositories Hardshelled capsules, which are normally used for dry, powdered ingredients or mini ature pellets, Both of these classes of capsules are made from aqueous solutions of gelling agents like:Animal protein mai nly gelatine And Nongelatin such as Plant polysacc harides or their derivatives like carrageenans and modified forms of starch and cellulose Despite the great advantages, of gelatin capsules’, gelatin has several drawbacks that limit its use fo r capsules The animal source of gelatin can be a p roblem for certain consumers such as vegetarians or vegans and religio us or ethnic groups, Since unmodified gelatin is prone to cross linking when in contact with aldehydes, solubility problems might be expected with certain fill formulations The nongelatin capsule shells are made up of such as Starch, HPMC, PVA, and Alginate Keywords: Gelatin/NonGelatin Material, capsule shell, Starch , HPMC, PVA, Alginate Introduction Soft gelatin capsules1 (referred to as soft elastic gelatin capsules, liquid gels or softgels) are a unique dru g delivery system that can provide distinct advantage s over traditional dosage forms such as tablets, hard gelatin capsules and liquids However due to econom ic, technical and patent constraints there are relative ly a few manufacturers of softgels in the world Softgel is a hermetically sealed, onepiece

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