Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable ...

Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable ...

17 Pages · 2015 · 907 KB · English

Biodegradable Sustained Release Drug. Delivery Systems Fabricated using a. Dissolvable Hydrogel Template Technology for the Treatment of Ocular Indications. Page 2. Financial Disclosures. Page 3. Presentation Overview. Page 4. Drawback of Current Microparticle Technology. Broad Particle Size 

Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable ... free download

Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable Hydrogel Template Technology for the Treatment of Ocular Indications Financial Disclosures Presentation Overview Drawback of Current Microparticle Technology Broad Particle Size Distribution Current Microemulsion Advantages of Ohr SR Microfabrication Narrow Particle Size Distribution Current Microemulsion Ohr SR Microfabrication Ohr Technology vs Other Ocular SR Systems Characteristic Bevacizumab Ranibizumab Aflibercept External Systems Implant Systems Micro emulsion Ohr Injectable through small gauge needle + + + + + Sustained release (4 6 months) + + + + + + Biodegradable: Does not require removal + + + + + + Initial release is controlled and tunable + + + Simple formulation and process designed for fragile biologics + + + + + + High drug loading capability + + + Load different drugs into same particle + + Microfabricated Microparticles Using a Dissolvable Hydrogel Template Microparticles are Released by Dissolving Hydrogel Template in Water Hydrogel template Gaudana R, Ananthula HK, Parenky A, Mitra AK Ocular Drug Delivery The AAPS Journal 2010;12(3):348 360 Routes of Administration Ohr Sustained Release Therapeutics Ophthalmic Indication: Glaucoma Tunable release capabilities for a hydrophilic drug molecule Burst R elease 1 Month 3 Month 4 Month Different formulations to meet desired target profiles 0 1 2 3 4 5 6 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Glaucoma Layering process reduces burst release for a hydrophilic drug molecule Layered Formulations Non Layered F ormulation 0 2 4 6 8 10 0 20 40 60 80 100 Days Cumulative Release (%) Ophthalmic Indication: Glaucoma Layering process reduces burst release Burst Release 1 Month 3 Month 4 Month Before Layering 0 1 2 3 4 5 6 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Inflammation Tunable release profile obtained using biodegradable polymers Polymer B Polymer A Polymer A+B 0 2 4 6 8 10 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Steroid Induced Glaucoma Sustained release obtained for a hydrophobic drug molecule OHR1031 57% Drug Load 0 1 2 3 4 5 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Retinal Diseases Sustained release obtained for a biologic ~150 kDa Polymer 1 Polymer 2 0 1 2 3 0 20 40 60 80 100 Months Cumulative Release (%) Summary

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