Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable ...

Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable ...

17 Pages · 2015 · 907 KB · English

Biodegradable Sustained Release Drug. Delivery Systems Fabricated using a. Dissolvable Hydrogel Template Technology for the Treatment of Ocular Indications. Page 2. Financial Disclosures. Page 3. Presentation Overview. Page 4. Drawback of Current Microparticle Technology. Broad Particle Size 

Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable ... free download

Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable Hydrogel Template Technology for the Treatment of Ocular Indications Financial Disclosures Presentation Overview Drawback of Current Microparticle Technology Broad Particle Size Distribution Current Microemulsion Advantages of Ohr SR Microfabrication Narrow Particle Size Distribution Current Microemulsion Ohr SR Microfabrication Ohr Technology vs Other Ocular SR Systems Characteristic Bevacizumab Ranibizumab Aflibercept External Systems Implant Systems Micro emulsion Ohr Injectable through small gauge needle + + + + + Sustained release (4 6 months) + + + + + + Biodegradable: Does not require removal + + + + + + Initial release is controlled and tunable + + + Simple formulation and process designed for fragile biologics + + + + + + High drug loading capability + + + Load different drugs into same particle + + Microfabricated Microparticles Using a Dissolvable Hydrogel Template Microparticles are Released by Dissolving Hydrogel Template in Water Hydrogel template Gaudana R, Ananthula HK, Parenky A, Mitra AK Ocular Drug Delivery The AAPS Journal 2010;12(3):348 360 Routes of Administration Ohr Sustained Release Therapeutics Ophthalmic Indication: Glaucoma Tunable release capabilities for a hydrophilic drug molecule Burst R elease 1 Month 3 Month 4 Month Different formulations to meet desired target profiles 0 1 2 3 4 5 6 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Glaucoma Layering process reduces burst release for a hydrophilic drug molecule Layered Formulations Non Layered F ormulation 0 2 4 6 8 10 0 20 40 60 80 100 Days Cumulative Release (%) Ophthalmic Indication: Glaucoma Layering process reduces burst release Burst Release 1 Month 3 Month 4 Month Before Layering 0 1 2 3 4 5 6 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Inflammation Tunable release profile obtained using biodegradable polymers Polymer B Polymer A Polymer A+B 0 2 4 6 8 10 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Steroid Induced Glaucoma Sustained release obtained for a hydrophobic drug molecule OHR1031 57% Drug Load 0 1 2 3 4 5 0 20 40 60 80 100 Months Cumulative Release (%) Ophthalmic Indication: Retinal Diseases Sustained release obtained for a biologic ~150 kDa Polymer 1 Polymer 2 0 1 2 3 0 20 40 60 80 100 Months Cumulative Release (%) Summary

------------- Read More -------------

Download biodegradable-sustained-release-drug-delivery-systems-fabricated-using-a-dissolvable.pdf

Biodegradable Sustained Release Drug Delivery Systems Fabricated using a Dissolvable ... related documents

Starting A Business handout - University of Minnesota Duluth

10 Pages · 2010 · 122 KB · English

What is the history of the business/idea? d. What industry is the business in? This is a list of suggested costs that can be involved in business startup.

adi as a Discourse Marker in Spoken Iraqi Arabic

9 Pages · 2015 · 926 KB · English

examples of what you might hear in typical spoken English which correspond to ؟adi in the present .. A: Is that neighbour blasting his music again?

Distributed Systems 12. Distributed Transactions

50 Pages · 2015 · 855 KB · English

Another Example Book a flight from Newark, New Jersey to Inyokern, California. No non-stop flights are available: Transaction begin 1. Reserve a seat for Newark to

Transcatheter Pulmonary Valve Replacement by Hybrid Approach Using a Novel Polymeric ...

9 Pages · 2014 · 4.36 MB · English

Prosthetic Heart Valve: Proof of Concept in Sheep. PLoS ONE 9(6): These authors contributed equally to this work. Ethics Statement . cefradine (25mg/kg, 1/12h) for 3 days and subcutaneous with preoperative values.

A Theory of Civil Conflict and Democracy in Rentier States

25 Pages · 2006 · 163 KB · English

have a higher probability of being a dictatorship than other countries. Auty and Gelb . 1 Of course, if the groups that engage in civil conflict are not the same as those who may alternatively run in an election, a Fearon, J. D. and Laitin, D. (2003), Ethnicity, Insurgency, and Civil War, American

SELECTING A JAVA DOWNLOAD FOR ALL OPERATING SYSTEMS

1 Pages · 2012 · 149 KB · English

SELECTING A JAVA DOWNLOAD FOR ALL OPERATING SYSTEMS Select your computer operating system from the list below to get the latest Java version for connecting to CCC Confer.

A Sweet Spot for Molecular Diagnostics: Coupling Isothermal Amplification and Strand Exchange ...

14 Pages · 2015 · 1.4 MB · English

successfully used for clinical diagnosis8–10, these methods are not readily adapted to point-of-care appli- cations. A simple molecular assay for MERS-CoV can potentially be developed by relying on the exqui- site sensitivity and extreme simplicity of isothermal amplification reactions11–16, su

A study of Sranan narrative 1863 -1869 O Petronella Breinburg Languages of Surinam

8 Pages · 2008 · 363 KB · English

late 1960 taught in schools); Portuguese (strongly influencing Saramakan) Scholars such as Arends (1999) pointed to the Portuguese elements of those There is also the work of scholars (Dimela Yekwai, 2000); Dalphines, 1985 

The Influence of Ethnicity, Women - Pitzer College | A Los Angeles

9 Pages · 2011 · 264 KB · English

Jewish Women Stereotypes Manipulative Overbearing Obnoxious Obsession with food Demanding Nagging Controlling + Latina Women Stereotypes